LymphedemaV1, France, Analysis, bibRecord, 000384

Molecular mechanisms of pituitary organogenesis: in search of novel regulatory genes

Identifieur interne : 000384 ( France/Analysis ); précédent : 000383; suivant : 000385

Molecular mechanisms of pituitary organogenesis: in search of novel regulatory genes

Auteurs : Sw Davis [États-Unis] ; F. Castinetti [États-Unis, France] ; Lr Carvalho [Brésil] ; Bs Ellsworth [États-Unis] ; Ma Potok [États-Unis] ; Rh Lyons [États-Unis] ; Ml Brinkmeier [États-Unis] ; Lt Raetzman [États-Unis] ; P. Carninci [Japon] ; Ah Mortensen [États-Unis] ; Y. Hayashizaki [Japon] ; Ijp Arnhold [Brésil] ; Bb Mendonca [Brésil] ; T. Brue [France] ; Sa Camper [États-Unis]

Source :

Molecular and cellular endocrinology [ 0303-7207 ] ; 2009.

RBID : PMC:2909473

Abstract

Defects in pituitary gland organogenesis are sometimes associated with congenital anomalies that affect head development. Lesions in transcription factors and signaling pathways explain some of these developmental syndromes. Basic research studies, including the characterization of genetically engineered mice, provide a mechanistic framework for understanding how mutations create the clinical characteristics observed in patients. Defects in BMP, WNT, Notch, and FGF signaling pathways affect induction and growth of the pituitary primordium and other organ systems partly by altering the balance between signaling pathways. The PITX and LHX transcription factor families influence pituitary and head development and are clinically relevant. A few later-acting transcription factors have pituitary-specific effects, including PROP1, POU1F1 (PIT1), and TPIT (TBX19), while others, such as NeuroD1 and NR5A1 (SF1), are syndromic, influencing development of other endocrine organs. We conducted a survey of genes transcribed in developing mouse pituitary to find candidates for cases of pituitary hormone deficiency of unknown etiology. We identified numerous transcription factors that are members of gene families with roles in syndromic or nonsyndromic pituitary hormone deficiency. This collection is a rich source for future basic and clinical studies.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909473

DOI: 10.1016/j.mce.2009.12.012
PubMed: 20025935
PubMed Central: 2909473

Affiliations:

Links to Exploration step

PMC:2909473

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p id="P1">Defects in pituitary gland organogenesis are sometimes associated with congenital anomalies that affect head development. Lesions in transcription factors and signaling pathways explain some of these developmental syndromes. Basic research studies, including the characterization of genetically engineered mice, provide a mechanistic framework for understanding how mutations create the clinical characteristics observed in patients. Defects in BMP, WNT, Notch, and FGF signaling pathways affect induction and growth of the pituitary primordium and other organ systems partly by altering the balance between signaling pathways. The PITX and LHX transcription factor families influence pituitary and head development and are clinically relevant. A few later-acting transcription factors have pituitary-specific effects, including PROP1, POU1F1 (PIT1), and TPIT (TBX19), while others, such as NeuroD1 and NR5A1 (SF1), are syndromic, influencing development of other endocrine organs. We conducted a survey of genes transcribed in developing mouse pituitary to find candidates for cases of pituitary hormone deficiency of unknown etiology. We identified numerous transcription factors that are members of gene families with roles in syndromic or nonsyndromic pituitary hormone deficiency. This collection is a rich source for future basic and clinical studies.</p>
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<name sortKey="Camper, Sa" sort="Camper, Sa" uniqKey="Camper S" first="Sa" last="Camper">Sa Camper</name>
<name sortKey="Castinetti, F" sort="Castinetti, F" uniqKey="Castinetti F" first="F" last="Castinetti">F. Castinetti</name>
<name sortKey="Ellsworth, Bs" sort="Ellsworth, Bs" uniqKey="Ellsworth B" first="Bs" last="Ellsworth">Bs Ellsworth</name>
<name sortKey="Lyons, Rh" sort="Lyons, Rh" uniqKey="Lyons R" first="Rh" last="Lyons">Rh Lyons</name>
<name sortKey="Mortensen, Ah" sort="Mortensen, Ah" uniqKey="Mortensen A" first="Ah" last="Mortensen">Ah Mortensen</name>
<name sortKey="Potok, Ma" sort="Potok, Ma" uniqKey="Potok M" first="Ma" last="Potok">Ma Potok</name>
<name sortKey="Raetzman, Lt" sort="Raetzman, Lt" uniqKey="Raetzman L" first="Lt" last="Raetzman">Lt Raetzman</name>
</country>
<country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Castinetti, F" sort="Castinetti, F" uniqKey="Castinetti F" first="F" last="Castinetti">F. Castinetti</name>
</region>
<name sortKey="Brue, T" sort="Brue, T" uniqKey="Brue T" first="T" last="Brue">T. Brue</name>
</country>
<country name="Brésil"><region name="État de São Paulo"><name sortKey="Carvalho, Lr" sort="Carvalho, Lr" uniqKey="Carvalho L" first="Lr" last="Carvalho">Lr Carvalho</name>
</region>
<name sortKey="Arnhold, Ijp" sort="Arnhold, Ijp" uniqKey="Arnhold I" first="Ijp" last="Arnhold">Ijp Arnhold</name>
<name sortKey="Mendonca, Bb" sort="Mendonca, Bb" uniqKey="Mendonca B" first="Bb" last="Mendonca">Bb Mendonca</name>
</country>
<country name="Japon"><noRegion><name sortKey="Carninci, P" sort="Carninci, P" uniqKey="Carninci P" first="P" last="Carninci">P. Carninci</name>
</noRegion>
<name sortKey="Hayashizaki, Y" sort="Hayashizaki, Y" uniqKey="Hayashizaki Y" first="Y" last="Hayashizaki">Y. Hayashizaki</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000384 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000384 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     PMC:2909473
   |texte=   Molecular mechanisms of pituitary organogenesis: in search of novel regulatory genes
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/France/Analysis/RBID.i   -Sk "pubmed:20025935" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/France/Analysis/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

Serveur d'exploration sur le lymphœdème

Molecular mechanisms of pituitary organogenesis: in search of novel regulatory genes

Molecular mechanisms of pituitary organogenesis: in search of novel regulatory genes

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.